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What to know for all three Thanksgiving Day NFL games: Picks, key stats and bold predictions

The Week 12 NFL schedule for the 2022 season begins with three Thanksgiving Day matchups, and we’ve got you covered with what you need to know. Our NFL Nation reporters bring us the keys to every game and a bold prediction for each matchup.

Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a game projection. ESPN researcher Kyle Soppe hands out helpful fantasy football intel as well. Finally, Seth Walder and Eric Moody give us final score picks for all three contests. Everything you want to know is here in one spot to help you get ready for a loaded afternoon of NFL football.

Let’s get into the full Thanksgiving Day slate, including Josh Allen against the Lions and an NFC East matchup between the Giants and Cowboys. The football-packed holiday culminates with a battle between the Patriots and Vikings. Who will take another step closer to the postseason with a win Thursday?

Jump to a matchup:BUF-DET Lions

What to know for fantasy: Buffalo running back Devin Singletary has reached 15 fantasy points three times this season, and two of those instances have come in the past two weeks. He has 133 total rushing yards (66.5 per game) and three rushing TDs over his past two games. See Week 12 rankings.

Betting nugget: Since 2004, Detroit is 3-11 against the spread and 0-14 outright as an underdog on Thanksgiving. Detroit’s last upset win on Thanksgiving happened in 2003 against Green Bay (+7). Read more.

Thanksgiving Day throwback: On Thanksgiving in 1997, Detroit running back Barry Sanders rushed for 167 yards and three touchdowns against the Bears in a 55-20 win for the Lions. Read more.

Moody’s pick: Bills 31, Lions 20Walder’s pick: Bills 34, Lions 17FPI prediction: BUF, 82.7% (by an average of 11.2 points)

Matchup must-reads: Bills credit Buffalo community after win: ‘That was for you’Williams taking leading role during Lions’ win streak

4:30 p.m. ET

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